The HPE ProLiant ML350 Gen10 4LFF CTO Server – 877625-B21 is a flexible, enterprise-class 4U tower server designed for small and medium-sized businesses, branch offices, remote sites, and data-center environments that require high expandability and storage capacity.
This model features 4 × LFF (3.5-inch) hot-plug drive bays as its standard drive cage and supports a dual-processor Intel Xeon Scalable architecture, 24 DDR4 DIMM slots, multiple PCIe Gen3 expansion slots, HPE Smart Array storage options, embedded 1GbE networking, and HPE iLO with Intelligent Provisioning. HPE identifies 877625-B21 specifically as the ML350 Gen10 4 LFF CTO Server.
Because this is a Configure-to-Order (CTO) platform, the processor, memory, storage drives, RAID controller, and other options are selected according to the required configuration. The base CTO SKU does not include a processor or fixed memory configuration as standard.
The ML350 Gen10 is a dual-socket server platform supporting Intel Xeon Scalable processors.
The 877625-B21 CTO configuration has two processor sockets available, but processors are not included as standard. Customers can configure one or two supported Intel Xeon Scalable processors depending on their performance requirements.
The platform supports Intel Xeon Scalable processors from the:
- Xeon Bronze family
- Xeon Silver family
- Xeon Gold family
- Xeon Platinum family
Supported processors include both 1st-generation and 2nd-generation Intel Xeon Scalable families, subject to the applicable HPE configuration and firmware requirements.
Processor: Not Included – Configurable
Processor Sockets: 2
Important: Do not put a specific Xeon processor in the product title unless you have verified the actual CPU installed in your refurbished unit.
Memory
The ML350 Gen10 provides 24 DDR4 DIMM slots.
It uses HPE DDR4 SmartMemory and supports advanced memory features such as ECC and other HPE memory protection technologies.
The platform supports configurations up to 3TB of memory using supported 128GB DDR4 DIMMs, depending on processor and memory configuration.
Supported memory technology includes:
- DDR4 RDIMM
- DDR4 LRDIMM
- HPE SmartMemory
Memory: Not Included – Configurable
Memory Type: DDR4 ECC HPE SmartMemory
DIMM Slots: 24
Maximum: Up to 3TB with supported configuration
Storage – 4LFF Hot Plug
The defining storage configuration of 877625-B21 is its:
4 × LFF Hot-Plug Drive Cage
LFF = Large Form Factor, referring to 3.5-inch drives.
The four drive bays support compatible enterprise SAS and SATA storage devices and provide hot-plug capability for supported configurations.
HPE identifies the included drive cage for 877625-B21 as 4 LFF.
Supported storage can include:
- 3.5-inch SAS HDD
- 3.5-inch SATA HDD
- 3.5-inch SAS SSD
- 3.5-inch SATA SSD
Drive Bays: 4 × LFF Hot Plug
Drive Size: 3.5-inch
Storage: No Drives Included – Configurable
Storage Expansion
One of the major advantages of the ML350 Gen10 platform is that the standard 4LFF configuration can be expanded.
Depending on the selected configuration and upgrade kits, the ML350 Gen10 platform can support up to:
12 × LFF drives
or alternative SFF/NVMe configurations.
HPE documentation lists support for configurations up to 12 LFF SAS/SATA HDD/SSD drives, with appropriate upgrade options.
This makes the ML350 Gen10 suitable for customers who need substantial internal storage capacity without moving immediately to an external storage enclosure.
Storage Controller & RAID
The ML350 Gen10 includes the HPE Smart Array S100i SR Gen10 as an embedded storage option.
The embedded controller provides software RAID functionality through the server's SATA storage architecture.
HPE lists:
- Embedded S100i software RAID
- 14 SATA ports
- Optional HPE modular Smart Array controller
- Optional PCIe stand-up storage controllers
The platform can therefore be configured for different levels of storage performance and RAID functionality.
Optional Smart Array controllers can be used when the customer requires dedicated hardware RAID and additional SAS storage capabilities.
Storage Controller: HPE Smart Array S100i SR Gen10
Optional: HPE Modular Smart Array / PCIe Smart Array Controllers
Network Connectivity
The ML350 Gen10 4LFF CTO configuration includes an embedded:
HPE Ethernet 1Gb 4-Port 369i Adapter
This provides:
4 × 1GbE Ethernet ports
The server can also be expanded with additional network adapters through its PCIe slots, including higher-speed networking depending on the selected adapter.
Network: HPE Ethernet 1Gb 4-Port 369i
Ports: 4 × 1GbE
PCIe Expansion
The ML350 Gen10 provides extensive PCIe expansion capability.
The 4LFF CTO configuration includes:
8 × PCIe Gen3 Expansion Slots
The slots support different PCIe electrical configurations, including x16 and x8 connections.
However, there is an important configuration detail:
PCIe slots 5–8 require the second processor to be installed.
This means that customers using only one CPU will not have access to all eight PCIe slots.
PCIe expansion can be used for:
- RAID controllers
- Fibre Channel HBAs
- High-speed NICs
- Additional storage controllers
- GPUs
- Other PCIe expansion cards
HPE iLO Management
The ML350 Gen10 includes HPE iLO with Intelligent Provisioning for remote server management.
HPE iLO allows administrators to perform tasks such as:
- Remote hardware monitoring
- Server health monitoring
- Remote console access
- Firmware management
- Remote troubleshooting
- Server configuration
- Operating-system deployment
HPE lists iLO Standard with Intelligent Provisioning as standard, with advanced iLO and OneView capabilities available through optional licensing.
Power Supply
The 877625-B21 configuration includes the HPE Flex Slot Redundant Power Supply cage and Power Distribution Board (PDB) as part of the base platform configuration.
The actual power supplies are configurable and can vary depending on the customer's build.
HPE Flex Slot power supply options include different wattage and efficiency levels, depending on the system configuration.
Power Supply: Configurable
PSU Cage: HPE Flex Slot RPS Cage + PDB
Do not list a specific PSU wattage unless you have confirmed the actual unit.
Cooling
The ML350 Gen10 4LFF configuration uses six standard fans according to the configuration information for this CTO model.
Additional fan configurations and redundant cooling options are available depending on the installed processors, storage, PCIe cards, and other components.
Adequate cooling is particularly important when the server is configured with:
- Two processors
- Multiple PCIe cards
- GPUs
- High-performance SAS storage
- Large memory configurations
Tower & Rack Capability
The ML350 Gen10 is primarily a 4U tower server.
One useful feature is that it can be converted for rack installation using an optional Tower-to-Rack Conversion Kit. HPE identifies 874578-B21 as the applicable tower-to-rack conversion kit.
This gives customers flexibility to start with a tower configuration and later install the system in a rack environment.
Form Factor: 4U Tower
Rack Conversion: Optional
USB & Connectivity
The ML350 Gen10 platform provides multiple USB interfaces for local management and peripheral connectivity.
The documented configuration includes:
- Front USB ports
- Rear USB ports
- Internal USB ports
- Front iLO Service Port
HPE's configuration information lists 2 front, 2 internal, and 4 rear USB ports, plus the front iLO service port.
Optical Drive Support
The ML350 Gen10 supports optional optical-drive configurations.
Depending on the configuration, customers can select options such as:
- Slimline DVD-ROM
- Slimline DVD-RW
Optical drives are not included as standard with the CTO base configuration.
Optical Drive: Optional / Not Included
GPU & PCIe Capability
The ML350 Gen10 platform provides significant expansion capability for graphics and accelerator workloads.
HPE documentation identifies support for GPU configurations, making the platform suitable for workloads where additional graphics or accelerator hardware is required.
Potential applications include:
- VDI
- Graphics workloads
- AI/ML-related workloads
- Video processing
- Technical computing
- GPU-assisted applications
The exact GPU compatibility depends on the selected configuration, power supplies, cooling, and riser arrangement.
Security & Management
The ML350 Gen10 includes HPE's enterprise server security and management features, including:
- HPE iLO
- Intelligent Provisioning
- Secure server management
- Firmware management
- HPE Silicon Root of Trust technologies
- HPE OneView support
These features are designed to help administrators manage the server throughout its operational lifecycle.
Ideal Applications
The HPE ProLiant ML350 Gen10 4LFF CTO Server can be configured for a wide range of business and enterprise workloads, including:
- File servers
- Database servers
- Application servers
- Backup servers
- Storage servers
- Virtualization
- VDI
- Branch-office infrastructure
- Remote-office infrastructure
- Business applications
- GPU-enabled workloads
- General enterprise workloads
Its dual-socket architecture and extensive expansion capability make it suitable for configurations that require more processing, memory, storage, or PCIe expansion than a basic single-socket tower server.
Key Advantages
The HPE ProLiant ML350 Gen10 877625-B21 provides:
- 4U tower form factor
- 2 processor sockets
- Intel Xeon Scalable processor support
- 24 DDR4 DIMM slots
- Up to 3TB memory with supported configuration
- 4 × LFF hot-plug bays
- Expandable to larger LFF configurations
- Embedded S100i RAID
- 14 SATA ports
- Optional HPE Smart Array controllers
- 4 × 1GbE embedded networking
- 8 PCIe Gen3 slots
- HPE iLO management
- Flexible power-supply options
- Optional tower-to-rack conversion
- GPU/accelerator expansion capability
